How can art generate innovation in companies? In this book, through the activities of the Fondazione Ermanno Casoli (FEC), the authors articulate a working method, born from more than ten years of experience in the field, which documents the effectiveness of the collaboration between the world of art and that of business. By exploring the relationship between art and opportunities for renewal of individual and professional identity within organizations, this book also illustrates the contribution of art in defining a new perspective on business performance. A specific chapter is dedicated to artistic interventions and the Covid-19 pandemic. Through art, a desire to keep together humanities and business thinking, employees’ rationality, emotions, and wellbeing, company performance and social care, can still emerge as a possibility, even in such challenging times. A possibility which deserves the authentic involvement of artists, workers, managers, researchers, and their social communities to consolidate.